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Isolation and Characterization of Dillenia Fruit Mucilage: A Novel Polymer for Microspheric Delivery of Losartan Potassium

[ Vol. 10 , Issue. 4 ]

Author(s):

Santanu Chakraborty*, Madhusmruti Khandai, Manami Dhibar, Shikha Yadav and Honey Kumari   Pages 314 - 325 ( 12 )

Abstract:


Objective: The present investigation was aimed to isolate, characterize and establish a natural polymer obtained from partially ripe and fresh fruits of Dillenia indica and its utility to deliver losartan potassium in a sustained manner from microspheric macromolecular dosage form.

Methods: All the microspheres were prepared by ionotropic gelation technique and investigated for various physico-chemical parameters along with in-vitro drug release studies to optimize the concentration of algino-Dillenia polymeric blend required to develop twice daily sustained release dosage form of losartan potassium.

Results: The functional characteristic studies and rheological behavior analysis suggested that extracted polysaccharide can be used as a viscosity modifying agent as well as sustain release ingredient. All the microsphere formulations exhibited excellent mucoadhesion properties and site-specific drug release. In-vitro studies revealed that the optimum concentration of algino-Dillenia polymeric blend is suitable to deliver losartan potassium in a sustained manner for a prolonged period of time. SEM study revealed that the microspheres were spherical in shape with a smooth outer surface having small cracks. XRD and DSC studies revealed that losartan potassium is present as an amorphous form in the prepared optimized microsphere formulation.

Conclusion: Thus, the present studies demonstrated that Dillenia fruit mucilage has an interesting rheological behavior which may be used as a viscosity modifying agent and exhibit promising properties of a sustained release dosage form to deliver losartan potassium from its microspheric dosage form.

Keywords:

Dillenia fruit mucilage, rheological behavior, viscosity modifying agent, polymer, microspheres, sustained release.

Affiliation:

Formulation Development Research Unit, Dr. B. C. Roy College of Pharmacy & AHS., Durgapur, Department of Pharmaceutics, Royal College of Pharmacy and Health Sciences, Berhampur, Formulation Development Research Unit, Dr. B. C. Roy College of Pharmacy & AHS., Durgapur, Department of Pharmaceutics, Galgotias University, Greater Noida, Uttar Pradesh, Formulation Development Research Unit, Dr. B. C. Roy College of Pharmacy & AHS., Durgapur

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