Bijaya Ghosh*, Niraj Mishra, Preeta Bose and Moumita Das Kirtania Pages 1 - 8 ( 8 )
Objective: Rheumatoid arthritis is a dreaded disease, characterized by pain, inflammation and stiffness of joint, leading to severe immobility problems. The disease shows circadian variation and usually gets most aggravated in early morning hours. Aceclofenac, a BCS Class II compound is routinely used in the treatment of pain and inflammation associated with rheumatoid arthritis. The objective of this study was to develop an osmotic delivery system of Aceclofenac that after administration at bed time will be able to deliver the drug in the morning hours.
Methods: A series of osmotically controlled systems of aceclofenac was developed by using lactose, sodium chloride and hydroxypropyl methylcellulose K100M as osmogens.Cellulose acetate (2% w/v in acetone) with varying concentrations of polyethylene glycol-400 was used as the coating polymer to create semi permeable membrane and dissolution was carried out in 290 mOsm phosphate buffer. Formulation optimization was done from four considerations: cumulative release at the end of 6 hours (lag time), cumulative release at the end of 7hours (burst time), steady state release rate and completeness of drug release.
Results: A formulation having swelling polymer hydroxypropyl methylcellulose in the core and lactose and sodium chloride as osmogens,polyethylene glycol-400 (16.39 %) as pore former, with a coating weight of 5% was a close fit to the target release profile and was chosen as the optimum formulation.
Conclusion: Aceclofenac tablets containing lactose, HPMC and sodiumchloride in the core, given a coating of cellulose actate and PEG-400 (5% wt gain) generated a release profile for optimum management of rheumatoid arthritic pain.
Aceclofenac, Osmotic delivery, Cellulose acetate, Pore former, PEG 400.
Department of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata- Group of Institutions. 124 B.L. Saha Road, Kolkata 700053, West Bengal, Department of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata- Group of Institutions. 124 B.L. Saha Road, Kolkata 700053, West Bengal, Department of Pharmacy, JIS University. 81, Nilgunj Rd, Jagarata Pally, Deshpriya Nagar, Agarpara, Kolkata, West Bengal 700109, School of Pharmaceutical Technology, Adamas University, Kolkata-700126, West Bengal